GLP-1 Weight Loss Trial Outcomes
Educational summary of clinical-trial outcomes reported for the FDA-approved brand-name GLP-1 products. These outcomes were generated using the FDA-approved reference products. Compounded versions are not FDA-evaluated, and trial outcomes should not be assumed to apply to them.
Results by Medication
Injectable pen
Ozempic Results
Semaglutide · Novo Nordisk
10-15% weight lossView results
Injectable pen
Wegovy Results
Semaglutide · Novo Nordisk
15-17% weight lossView results
Injectable pen
Mounjaro Results
Tirzepatide · Eli Lilly
15-21% weight lossView results
Injectable pen
Zepbound Results
Tirzepatide · Eli Lilly
20-25% weight lossView results
Oral tablet
Rybelsus Results
Semaglutide · Novo Nordisk
5-10% weight lossView results
Oral tablet
Oral Wegovy Results
Semaglutide · Novo Nordisk
15-17% weight lossView results
Frequently Asked Questions
Were the brand-name products studied in clinical trials?
The FDA-approved brand-name semaglutide and tirzepatide products were each evaluated in pivotal clinical-trial programs reviewed by the FDA as part of their approval. Those published outcomes were generated using the FDA-approved reference products. Compounded versions are not FDA-evaluated, and brand-product trial outcomes should not be assumed to apply to them.
How is treatment progress typically monitored over time?
Weight change is usually tracked over a course of consistent dosing, with periodic check-ins to review tolerance and adjust the plan. Your Weight Method provider sets expectations based on your individual clinical profile rather than on brand-product trial figures.
Do compounded medications produce the same outcomes as the brand-name trials?
Clinical-trial outcomes were generated using the FDA-approved brand-name products. Compounded medications are not FDA-evaluated, and brand-product trial outcomes should not be assumed to apply to compounded versions. Individual results vary.
What did the brand-product trials report about post-treatment outcomes?
Published extension studies of the brand-name products reported some weight regain after discontinuation. Maintaining results long-term typically involves lifestyle changes and, in some cases, continued treatment.
What factors affect individual response?
Starting BMI, adherence to the prescribed schedule, diet, physical activity, and individual metabolism all influence response. Your Weight Method provider will set expectations based on your individual clinical profile.