From 2,000+ patients · Semaglutide is already seeing results
Semaglutide is an FDA-approved GLP-1 receptor agonist for chronic weight management. In the STEP 1 trial (NEJM, 2021), semaglutide achieved an average 14.9% body weight loss. Weight Method offers Semaglutide starting at $297/month, prescribed by licensed providers with direct shipping.
Key Fact
Semaglutide is a GLP-1 receptor agonist that produces an average of 14.9% body weight loss over 68 weeks (STEP 1 trial, NEJM 2021). FDA-approved as Wegovy for chronic weight management, it is administered as a once-weekly injection starting at 0.25mg and titrating to 2.4mg. At Weight Method, semaglutide starts at $297/month — 75-80% less than retail pharmacy pricing.
Source: STEP 1 Trial — Wilding et al., NEJM 2021
How does Semaglutide work for weight loss?
Semaglutide mimics GLP-1 hormones to reduce hunger and slow gastric emptying, helping patients lose 15-20% of body weight over 68 weeks.
Semaglutide works by mimicking GLP-1, a naturally occurring hormone your body releases after eating that signals fullness to your brain. By activating GLP-1 receptors in the hypothalamus, semaglutide reduces hunger, curbs cravings, and helps you feel satisfied with smaller portions. It also slows gastric emptying, meaning food stays in your stomach longer, which naturally extends the feeling of satiety between meals. Over time, this leads to a sustained caloric deficit without the constant willpower battle associated with traditional dieting.
What is the Semaglutide dosing schedule?
Start at 0.25mg weekly, escalating monthly through 0.5mg, 1mg, 1.7mg, up to 2.4mg maintenance dose over 16-20 weeks.
Treatment follows a gradual dose-escalation protocol designed to minimize side effects and allow your body to adjust. You start at 0.25mg once weekly for the first four weeks, then increase to 0.5mg for weeks five through eight. From there, your provider may increase the dose monthly in increments -- 1mg, 1.7mg, and up to a maximum of 2.4mg -- based on your tolerance and weight loss progress. Most patients reach their maintenance dose within 16 to 20 weeks, and your Weight Method provider monitors your progress at every step to optimize results.
What are the common side effects of Semaglutide?
The most common side effects are nausea, vomiting, diarrhea, and constipation, typically mild and decreasing after the first 4-8 weeks of treatment.
The most common side effects of semaglutide are gastrointestinal and typically occur during the first few weeks or after dose increases. These include nausea, diarrhea, vomiting, constipation, and abdominal discomfort -- most of which are mild to moderate and subside as your body adjusts. The gradual dose-escalation schedule is specifically designed to reduce these effects. Serious side effects are rare but can include pancreatitis, gallbladder issues, and allergic reactions; your Weight Method provider will review your full medical history to ensure semaglutide is safe for you.
Who qualifies for Semaglutide treatment?
Adults with BMI ≥30, or BMI ≥27 with conditions like type 2 diabetes or high blood pressure, aged 18+, who are not pregnant.
You may be eligible for semaglutide if you have a BMI of 30 or greater (classified as obesity) or a BMI of 27 or greater with at least one weight-related health condition such as type 2 diabetes, high blood pressure, or high cholesterol. Candidates must be 18 years of age or older and should not be pregnant, planning to become pregnant, or breastfeeding. A personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) is a contraindication. Take the Weight Method quiz to find out in under two minutes whether semaglutide is right for you.
