Semaglutide Dosage Calculator
Compounded semaglutide is dispensed in multi-dose vials at concentrations typically ranging from 1 mg/mL to 5 mg/mL. Unlike brand-name pens (Ozempic, Wegovy) that have built-in dose dials, compounded vials require you to calculate and draw the correct number of units on a U-100 insulin syringe. Getting this conversion right matters — your prescribed milligram dose translates to a specific volume that changes depending on your vial's concentration.
Select Dose
Vial Concentration
How many units is 0.25 mg of Semaglutide at 2 mg/mL?
Draw
12.5units
0.13 mL on a U-100 insulin syringe
0.25 mg ÷ 2 mg/mL × 100 = 12.5 units
For educational purposes only. Always follow your provider's instructions.
Quick Reference Table
All dose × concentration combinations
| Dose | 2 mg/mL | 2.5 mg/mL | 5 mg/mL |
|---|---|---|---|
| 0.25 mg | 12.5 | 10 | 5 |
| 0.5 mg | 25 | 20 | 10 |
| 1 mg | 50 | 40 | 20 |
| 1.7 mg | 85* | 68* | 34 |
| 2.4 mg | 120* | 96* | 48 |
Values in U-100 insulin syringe units
* Exceeds 50 units (0.5 mL) — may require splitting into two injections
Brand Pen Schedules
Official titration schedules for pre-filled pens
Ozempic
| Weeks | Dose | Phase |
|---|---|---|
| 1-4 | 0.25 mg | Initiation |
| 5-8 | 0.5 mg | Escalation |
| 9+ | 1 mg | Maintenance |
| 13+ | 2 mg | Maximum (if needed) |
Wegovy
| Weeks | Dose | Phase |
|---|---|---|
| 1-4 | 0.25 mg | Initiation |
| 5-8 | 0.5 mg | Escalation |
| 9-12 | 1 mg | Escalation |
| 13-16 | 1.7 mg | Escalation |
| 17+ | 2.4 mg | Maintenance |
Frequently Asked Questions
How many units is 0.25 mg of semaglutide?
It depends on your vial concentration. With a 5 mg/mL vial, 0.25 mg equals 5 units on a U-100 syringe. With a 2.5 mg/mL vial, it equals 10 units. With a 1 mg/mL vial, it equals 25 units. Always check your vial label and use the formula: units = (dose in mg / concentration in mg per mL) x 100.
How do I convert semaglutide units to milligrams?
Multiply the number of units by the vial concentration, then divide by 100. For example, 10 units drawn from a 5 mg/mL vial delivers 0.5 mg of semaglutide (10 x 5 / 100 = 0.5 mg). This formula works for any U-100 syringe and any vial concentration.
What concentration does compounded semaglutide come in?
Common compounding pharmacy concentrations are 1 mg/mL, 2 mg/mL, 2.5 mg/mL, and 5 mg/mL. Higher concentrations mean smaller injection volumes for the same milligram dose. Your pharmacy label will clearly state the concentration — always verify it before drawing your dose.
How do I draw semaglutide from a vial with an insulin syringe?
Use a new, sterile U-100 insulin syringe. Wipe the vial stopper with alcohol. Pull air into the syringe equal to the volume you need, inject the air into the vial, invert it, and slowly draw to the correct unit marking. Tap out air bubbles and adjust to the precise line. Inject subcutaneously into the abdomen, thigh, or upper arm at a 90-degree angle.
How many units is 0.5 mg of semaglutide in a 5 mg/mL vial?
10 units. The calculation: 0.5 mg divided by 5 mg/mL equals 0.10 mL, and 0.10 mL on a U-100 syringe is 10 units. This is a common starting maintenance dose for patients who have completed the initial 0.25 mg escalation phase.
What is the semaglutide dosage chart for a 5 mg/mL vial?
For a 5 mg/mL compounded vial: 0.25 mg = 5 units, 0.5 mg = 10 units, 1.0 mg = 20 units, 1.5 mg = 30 units, 2.0 mg = 40 units, and 2.4 mg = 48 units. These values apply specifically to the 5 mg/mL concentration. Different concentrations will produce different unit counts for the same milligram dose.
Is the dosing the same for Ozempic and Wegovy?
No. Ozempic and Wegovy both contain semaglutide but have different approved dose ranges. Ozempic maintenance doses are typically 0.5 mg, 1 mg, or 2 mg weekly (primarily for diabetes). Wegovy uses a 5-step escalation up to 2.4 mg weekly (for weight management). Compounded semaglutide follows a similar escalation, but your provider sets the specific dose based on your treatment goals.
How many doses can I get from one semaglutide vial?
It depends on the vial size and your weekly dose. A standard 5 mL vial at 5 mg/mL contains 25 mg total. At a 0.25 mg weekly dose, that is 100 weeks of doses. At 1 mg weekly, that is 25 weeks. At 2.5 mg weekly, that is 10 weeks. Your pharmacy may dispense smaller vials — check the total volume and concentration to calculate how many weeks each vial covers.
Can I use a syringe other than a U-100 for semaglutide?
U-100 insulin syringes are the standard for compounded GLP-1 injections and what this calculator is calibrated for. Using a different syringe type (such as a tuberculin syringe marked in mL instead of units) requires a different calculation. Unless your provider specifically instructs otherwise, always use a U-100 insulin syringe for accuracy and safety.
What is the difference between a semaglutide injection units calculator and a dosage chart?
A dosage chart provides a static reference for one specific concentration, showing preset mg-to-unit conversions. A calculator lets you input any vial concentration and any milligram dose to get a custom result. If your compounding pharmacy uses a non-standard concentration, a calculator gives you the flexibility a fixed chart cannot.