0.25 mg Semaglutide Dosage Calculator
Convert your starting dose of semaglutide to the exact number of units for your vial concentration.
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Vial Concentration
How many units is 0.25 mg of Semaglutide at 2 mg/mL?
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12.5units
0.13 mL on a U-100 insulin syringe
0.25 mg ÷ 2 mg/mL × 100 = 12.5 units
For educational purposes only. Always follow your provider's instructions.
Quick Reference Table
All dose × concentration combinations
| Dose | 2 mg/mL | 2.5 mg/mL | 5 mg/mL |
|---|---|---|---|
| 0.25 mg | 12.5 | 10 | 5 |
| 0.5 mg | 25 | 20 | 10 |
| 1 mg | 50 | 40 | 20 |
| 1.7 mg | 85* | 68* | 34 |
| 2.4 mg | 120* | 96* | 48 |
Values in U-100 insulin syringe units
* Exceeds 50 units (0.5 mL) — may require splitting into two injections
About the 0.25 mg Dose
The 0.25 mg dose is the starting dose for both Ozempic and Wegovy during weeks 1 through 4 of treatment. This low introductory dose allows your body to adjust to semaglutide and helps minimize gastrointestinal side effects. Most patients remain at this dose for four weeks before escalating to 0.5 mg.
Frequently Asked Questions
How many units is 0.25 mg semaglutide in a 2 mg/mL vial?
In a 2 mg/mL vial, 0.25 mg semaglutide equals 12.5 units. The calculation is (0.25 / 2) x 100 = 12.5 units. For a 2.5 mg/mL vial, it would be 10 units, and for a 5 mg/mL vial, it would be 5 units.
How long do I stay on the 0.25 mg semaglutide dose?
The 0.25 mg dose is used for the first 4 weeks of treatment for both Ozempic and Wegovy. This starting phase allows your body to adjust to the medication. After 4 weeks, your provider will typically increase your dose to 0.5 mg.
Why do I start on such a low dose of semaglutide?
The 0.25 mg starting dose is intentionally low to help your body acclimate to semaglutide gradually. Starting at a lower dose significantly reduces the risk of nausea, vomiting, and other gastrointestinal side effects that are common when beginning GLP-1 therapy.
Is the 0.25 mg starting dose the same for Ozempic and Wegovy?
Yes, both Ozempic and Wegovy use 0.25 mg as their starting dose for weeks 1 through 4. However, their titration schedules diverge after this point. Ozempic escalates to 0.5 mg and then 1 mg, while Wegovy continues escalating through 0.5 mg, 1 mg, 1.7 mg, and ultimately 2.4 mg.