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Ozempic vs Mounjaro: Two Separate FDA-Approved Medications

Two FDA-approved branded medications for type 2 diabetes — semaglutide and the dual-action tirzepatide. Here's how they differ.

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Ozempic vs Mounjaro: both are FDA-approved GLP-1 medications for weight loss. Ozempic (semaglutide) and Mounjaro (tirzepatide) differ in mechanism and clinical efficacy. Weight Method offers both from $199/month with virtual consultations and licensed providers.

Overview

Ozempic (semaglutide, Novo Nordisk) and Mounjaro (tirzepatide, Eli Lilly) are two separate FDA-approved, once-weekly injectable pens indicated for type 2 diabetes, made by different manufacturers and working through different mechanisms. Ozempic is a GLP-1 receptor agonist; Mounjaro is a dual GIP/GLP-1 receptor agonist. Weight Method does not dispense or prescribe either brand-name product; our program provides compounded semaglutide and compounded tirzepatide through licensed providers and U.S.-licensed pharmacies. Which medication is appropriate for you is a decision made by a licensed provider based on your individual medical profile.

Key Fact

Ozempic (semaglutide) is a GLP-1 receptor agonist; Mounjaro (tirzepatide) is a dual GIP/GLP-1 receptor agonist. They are separate FDA-approved branded products for type 2 diabetes from different manufacturers — and both are different from Weight Method's compounded program.

Source: FDA prescribing information (Ozempic; Mounjaro)

Ozempic

Novo Nordisk
semaglutide
Type 2 diabetes
2017
Injectable pen
Once weekly
0.25mg, 0.5mg, 1mg, 2mg
10-15%
$199/mo

Mounjaro

Eli Lilly
tirzepatide
Type 2 diabetes
2022
Injectable pen
Once weekly
2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, 15mg
15-21%
$329/mo
 OzempicMounjaro
ManufacturerNovo NordiskEli Lilly
Active Ingredientsemaglutidetirzepatide
FDA IndicationType 2 diabetesType 2 diabetes
FDA Approval20172022
FormulationInjectable penInjectable pen
FrequencyOnce weeklyOnce weekly
Available Doses0.25mg, 0.5mg, 1mg, 2mg2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, 15mg
Avg. Weight Loss10-15%15-21%
Our Price$199/mo$329/mo

Key Differences

Ozempic and Mounjaro are different molecules from different manufacturers, each FDA-approved for type 2 diabetes. Ozempic acts on the GLP-1 receptor; Mounjaro acts on both the GIP and GLP-1 receptors. Which mechanism and medication is clinically appropriate for any individual depends on that person's medical history and is determined by a licensed provider, not by a general comparison. Through Weight Method, the compounded semaglutide program is $154/mo and the compounded tirzepatide program is $329/mo, each a flat all-inclusive monthly rate. The two have similar gastrointestinal side effect profiles.

Verdict

Ozempic and Mounjaro are distinct FDA-approved branded products from different manufacturers with different mechanisms; neither is what Weight Method dispenses. The right option for an individual depends on that person's medical profile and is determined by a licensed provider. Through Weight Method, compounded semaglutide is $154/mo and compounded tirzepatide is $329/mo, with provider guidance on what fits your needs.

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Your Treatment Options

Compounded GLP-1 medications dispensed by U.S.-licensed 503A pharmacies.

Starting at$199/mo
Semaglutide
Most PopularIn Stock

Semaglutide

Compounded semaglutide. Once-weekly subcutaneous injection.

  • Weekly injection
  • Gradual dose increase
  • Provider monitoring
  • Free shipping
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Tirzepatide
In Stock

Tirzepatide

Compounded tirzepatide. Dual-action GLP-1/GIP, once-weekly subcutaneous injection.

  • Weekly injection
  • Dual hormone action
  • Provider monitoring
  • Free shipping
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Frequently Asked Questions

What's the difference between Ozempic and Mounjaro?
They are different molecules from different manufacturers, both FDA-approved for type 2 diabetes. Ozempic acts on the GLP-1 receptor; Mounjaro acts on both the GIP and GLP-1 receptors. Which one is appropriate for a given person is a clinical decision made by a licensed provider based on their individual health profile.
How do the mechanisms of Ozempic and Mounjaro differ?
Ozempic contains semaglutide, a single-receptor GLP-1 agonist. Mounjaro contains tirzepatide, a dual GIP/GLP-1 receptor agonist that acts on two incretin pathways. Both molecules belong to the broader incretin-based class. Whether either approach is appropriate for an individual is determined by a licensed provider.
Can I switch from Ozempic to Mounjaro?
Any change between medications should occur under medical supervision, and Weight Method dispenses neither brand-name product. Whether a transition is appropriate and how dosing is managed is determined by a licensed provider based on your individual medical profile. Discuss timing and dose transitions during your Weight Method consultation.
Do Ozempic and Mounjaro have the same side effects?
The side effect profiles are similar — both commonly cause nausea, vomiting, diarrhea, and decreased appetite, especially during dose escalation. Individual responses vary. A licensed provider monitors tolerability for patients in Weight Method's compounded program.
How much does Weight Method's program cost per month?
Weight Method does not dispense or prescribe brand-name Ozempic® or Mounjaro®. Weight Method's compounded semaglutide program is $154/mo and compounded tirzepatide program is $329/mo, dispensed by U.S.-licensed 503A compounding pharmacies. Each is a flat monthly rate that includes the medication, licensed provider oversight, and shipping. Compounded medications are not FDA-approved.

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