Once weekly·Injectable pen

Mounjaro Dosing Guide

Mounjaro (tirzepatide) is a once-weekly injectable dual GIP/GLP-1 receptor agonist delivered in a single-dose pre-filled pen. It works on two incretin pathways for enhanced blood sugar control and weight loss. Your Weight Method provider will start you at the lowest dose and increase gradually every 4 weeks based on tolerability. The maximum dose is 15 mg weekly.

2.5mg5mg7.5mg10mg12.5mg15mg
Updated March 2026Medically reviewed by licensed providers

Mounjaro dosing starts at a low dose and gradually increases over 16-20 weeks to minimize side effects. Weight Method providers create personalized titration schedules. Treatment starts at $297/month with direct-to-door shipping.

Key Fact

Mounjaro dosing: start at 2.5mg weekly for 4 weeks, then 5mg for 4 weeks. Increase in 2.5mg steps (7.5mg → 10mg → 12.5mg → 15mg) based on response. Maintenance typically 10-15mg. Once-weekly injection, any time of day.

Source: Mounjaro FDA prescribing information

What is the dosing schedule?

Start at 2.5mg weekly for 4 weeks, then 5mg for 4 weeks. Provider may increase by 2.5mg every 4 weeks through 7.5mg, 10mg, 12.5mg, up to 15mg maximum.

Start at 2.5 mg once weekly for 4 weeks, then increase to 5 mg weekly for 4 weeks. From there, your Weight Method provider may increase by 2.5 mg every 4 weeks as tolerated — moving through 7.5 mg, 10 mg, 12.5 mg, and up to a maximum of 15 mg weekly. Not every patient needs the highest dose; your provider will find the dose that balances efficacy with tolerability. Inject on the same day each week.

How do you administer the injection?

Inject subcutaneously once weekly in the abdomen, thigh, or upper arm. Single-dose pen with automatic needle retraction. Press and hold the purple button for 10 seconds.

Inject Mounjaro subcutaneously into the abdomen, thigh, or upper arm using the single-dose pen. Remove the gray base cap, place the clear base flat against your skin, and press and hold the purple injection button. You will hear a click when the injection starts — continue holding for 10 seconds until a second click confirms delivery. The needle retracts automatically. Rotate injection sites weekly to prevent irritation.

What should you do if you miss a dose?

If within 4 days (96 hours) of the scheduled day, take the missed dose. If more than 4 days have passed, skip it and resume your regular weekly schedule.

If you miss a dose, take it within 4 days (96 hours) of the scheduled day. If more than 4 days have passed, skip the missed dose and take the next one on your regular day. Do not take two doses within 3 days of each other. Reach out to your Weight Method provider if you frequently miss doses, as consistency is important for optimal results.

How should you store the medication?

Store unused pens refrigerated at 36-46°F (2-8°C). At room temperature (up to 86°F), pens last a maximum of 21 days. Do not freeze. Each pen is single-use.

Store unused Mounjaro pens in the refrigerator at 36-46 degrees F (2-8 degrees C). Do not freeze. If needed, an unused pen can be stored at room temperature up to 86 degrees F (30 degrees C) for a maximum of 21 days. After 21 days at room temp, the pen must be discarded. Keep pens in original packaging until ready to use. Each pen is single-use — discard after the injection.

Frequently Asked Questions

Mounjaro (tirzepatide) activates both GIP and GLP-1 receptors, while semaglutide targets only GLP-1. This dual action may provide stronger appetite suppression and blood sugar control. Your Weight Method provider can help determine which medication is best for your profile.

No. Many patients achieve their goals at 5 mg, 7.5 mg, or 10 mg. Your Weight Method provider will only increase your dose if you need more effect and are tolerating the current dose well. The lowest effective dose is always preferred.

Mounjaro's prescribing information specifies a 4-day (96-hour) window for missed doses to maintain consistent drug levels. Taking a dose after this window could disrupt your weekly schedule and increase side effect risk.

Yes, and you should. Rotate between abdomen, thigh, and upper arm each week regardless of your dose level. Consistent rotation helps prevent injection-site reactions and ensures steady medication absorption.

You will hear two clicks: the first when the injection begins and the second when it is complete. The process takes about 5-10 seconds. After the second click, the gray plunger will be visible in the window, confirming full delivery. Do not pull the pen away before the second click.

Discard it. After 21 days at room temperature, the medication may lose potency. Do not use a pen that has exceeded its storage window. Contact your Weight Method care team for a replacement.

Yes. Mounjaro can be injected at any time of day, with or without food. You do not need to inject at the same time each week — only on the same day. If you need to change your injection day, ensure at least 3 days have passed since your last dose to maintain consistent drug levels.

Taking more than the prescribed dose of tirzepatide can cause severe nausea, vomiting, and potentially dangerous drops in blood sugar, especially if you also take diabetes medications. If you suspect an overdose, contact your Weight Method provider or seek emergency care immediately. Do not attempt to counteract the dose on your own.

Mounjaro is intended for long-term use, as the metabolic effects of tirzepatide are medication-dependent. Clinical data shows that weight and blood sugar improvements reverse after discontinuation. Your Weight Method provider will discuss a sustainable long-term plan, which may include finding your optimal maintenance dose rather than always targeting the maximum 15mg.

No. Each Mounjaro pen delivers a single pre-set dose, and dose adjustments should only be made by your provider based on clinical assessment. Increasing the dose too quickly leads to significantly worse side effects, while reducing it without guidance can compromise your results. Your Weight Method provider manages all titration decisions.

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