Zepbound (tirzepatide) is an FDA-approved once-weekly injectable specifically indicated for chronic weight management. It contains the same active ingredient as Mounjaro — tirzepatide — and uses an identical dosing schedule and pen design. Your Weight Method provider will customize your escalation based on weight loss goals and tolerability, with doses ranging from 2.5 mg to 15 mg weekly.
Zepbound dosing starts at a low dose and gradually increases over 16-20 weeks to minimize side effects. Weight Method providers create personalized titration schedules. Treatment starts at $297/month with direct-to-door shipping.
Key Fact
Zepbound follows the same tirzepatide protocol as Mounjaro: 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg, increasing every 4 weeks. Maximum dose 15mg weekly. Pre-filled pen, subcutaneous injection.
Source: Zepbound FDA prescribing information
Identical to Mounjaro: 2.5mg weekly for 4 weeks, then 5mg, increasing by 2.5mg every 4 weeks up to 15mg maximum. Dose customized to weight loss goals and tolerability.
Begin at 2.5 mg once weekly for 4 weeks, then increase to 5 mg weekly for 4 weeks. Your Weight Method provider may continue increasing by 2.5 mg every 4 weeks through 7.5 mg, 10 mg, 12.5 mg, and up to the maximum of 15 mg weekly. The escalation pace depends on your side effect profile and weight loss progress. Inject on the same day each week for best results.
Inject subcutaneously once weekly in the abdomen, thigh, or upper arm. Two-step pen: remove cap, press firmly against skin and hold purple button for 10 seconds until second click.
Inject Zepbound subcutaneously in the abdomen, thigh, or upper arm. The single-dose pen has a simple two-step process: remove the gray cap and press the pen firmly against your skin, then press and hold the purple button for 10 seconds until you hear the second click. The needle is hidden and retracts automatically after injection. Rotate your injection site each week to minimize skin reactions.
Take missed dose within 4 days (96 hours) of scheduled day. If more than 4 days late, skip that dose entirely and resume on the next regular injection day.
Take a missed dose within 4 days (96 hours) of the scheduled injection day. If more than 4 days have passed, skip that dose and resume your regular weekly schedule. Never administer two doses within 3 days. If you miss doses frequently, inform your Weight Method provider so they can reassess your treatment plan and consider whether dose adjustment is needed.
Store refrigerated at 36-46°F (2-8°C). Room temperature storage (up to 86°F) for a maximum of 21 days. Never freeze. Discard frozen pens. Single-use only.
Store Zepbound pens in the refrigerator at 36-46 degrees F (2-8 degrees C) until ready for use. Do not freeze, and discard any pen that has been frozen. Pens may be kept at room temperature (up to 86 degrees F / 30 degrees C) for a maximum of 21 days. Protect from direct light and extreme heat. Each pen is for single use only — do not save or reuse a partially administered pen.
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