Wegovy (semaglutide) is an FDA-approved once-weekly injectable for chronic weight management, delivered via single-dose pre-filled pens. It uses a 5-step dose escalation over 16 weeks before reaching the full maintenance dose of 2.4 mg. Each dose level has its own dedicated pen, and your Weight Method provider will prescribe the appropriate strength as you progress through the schedule.
Wegovy dosing starts at a low dose and gradually increases over 16-20 weeks to minimize side effects. Weight Method providers create personalized titration schedules. Treatment starts at $297/month with direct-to-door shipping.
Key Fact
Wegovy titration: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg, each step lasting 4 weeks (16 weeks to maintenance). Once-weekly subcutaneous injection. The gradual escalation minimizes nausea and other GI side effects.
Source: Wegovy FDA prescribing information
Wegovy follows a 5-step escalation: 0.25mg for 4 weeks, then 0.5mg, 1mg, 1.7mg, up to 2.4mg maintenance — one injection weekly over 16 weeks total.
The 5-step escalation begins at 0.25 mg weekly for 4 weeks, then 0.5 mg for 4 weeks, 1 mg for 4 weeks, 1.7 mg for 4 weeks, and finally 2.4 mg weekly as the maintenance dose. This gradual approach over 16 weeks helps your body adjust and reduces gastrointestinal side effects. Inject on the same day each week — you may change the day as long as at least 2 days separate consecutive doses. Your Weight Method provider may slow the escalation if side effects are significant.
Inject subcutaneously once weekly in the abdomen, thigh, or upper arm. Each pen is single-use and pre-set — no dialing required. Hold for 5-10 seconds until the click.
Inject Wegovy subcutaneously into the abdomen, thigh, or upper arm. Each pen is single-use and pre-set to deliver the correct dose — no dialing required. Clean the injection site, remove the pen cap, place the pen flat against your skin, unlock, and press the injection button. Hold for 5-10 seconds until you hear a second click confirming full delivery. Rotate injection sites weekly.
If less than 5 days late, take the missed dose immediately. If more than 5 days, skip it and resume your regular schedule. Missing several weeks may require restarting escalation.
If you miss your scheduled dose, take it as soon as you remember within 5 days. If more than 5 days have passed since the missed dose, skip it and resume on your next regularly scheduled day. Do not double up on doses. If you miss several consecutive doses, contact your Weight Method provider — you may need to restart at a lower dose to avoid gastrointestinal side effects.
Store unused pens refrigerated at 36-46°F (2-8°C). Out of the fridge, pens last up to 28 days at room temperature. Do not freeze. Each pen is single-use.
Store unused Wegovy pens in the refrigerator at 36-46 degrees F (2-8 degrees C). Do not freeze, and discard any pen that has been frozen. After removing from the refrigerator, pens can be stored at room temperature (up to 86 degrees F / 30 degrees C) for up to 28 days. Keep pens in original carton to protect from light. Each pen is single-use — discard after injection even if liquid remains.
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